Many studies show lasers can produce comparable or even superior outcomes, particularly as an adjunct therapy, while offering benefits like less pain, faster healing, and better patient acceptance. 

Scientific articles with evidence supporting laser efficacy:

• Yukna, R. A., et al. (2007): In this histological study, researchers applied the Laser-Assisted New Attachment Procedure (LANAP) using an Nd:YAG laser and found evidence of true periodontal regeneration in humans. The study showed new cementum, new periodontal ligament fibers, and new alveolar bone forming on previously diseased root surfaces, setting a benchmark for regenerative periodontal therapy.

• Gaspirc, B., & Skaleric, U. (2014): This randomized controlled clinical trial compared an Er:YAG laser-assisted procedure with conventional flap surgery. After five years, the laser-treated sites showed significantly greater improvements in both probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain compared to the conventionally treated sites.

• Bian, Z., et al. (2025): A split-mouth randomized controlled trial found that using an Nd:YAG laser as an adjunct to traditional subgingival instrumentation improved outcomes in deep periodontal pockets (≥7mm). While the overall clinical impact was modest, the laser selectively enhanced the reduction of pocket depth and inflammatory markers in these severe defects.

• MDPI, et al. (2024): A study on Er,Cr:YSGG laser-assisted surgery found outcomes comparable to conventional surgery in reducing pocket depth and improving clinical attachment level. However, the laser-treated group showed statistically significant reductions in plaque and gingival inflammation compared to the conventional group.

• A recent meta-analysis (2024): One meta-analysis found that laser-assisted periodontal therapy (LAPT) resulted in statistically significant greater reductions in pocket depth (PD) and improvements in clinical attachment level (CAL) compared to scaling and root planing (SRP) alone after 3 and 6 months.